Research hotspots commonly used in star mouse data sharing--Fgf21 knockout mice
I am this lab.
The most awkward mouse
More than two years after the launch of the Sexual Bio-CRISPR-AI Knockout Sperm Library, it has pushed 2000+ research groups to accelerate research and help 300+ companies to compete against drugs in research and development. We statistically analyzed the top 10 best-selling CRISPR-AI knockout mouse strains, perhaps reflecting some of the current research hotspots. These lines cover five research areas of metabolic diseases, neuroscience, immunity and inflammation, tumors, m6A methylation modifications and related diseases. Come and see if there are any strains that you are interested in!
In the future, the contest will continue to introduce you to some of the star rat strains. I hope that your research will be helpful and I look forward to your continued attention. The main character we are going to talk about today is the Fgf21 knockout mouse.
The first bullet of the CRISPR-AI star mouse--Fgf21 knockout mouse
Background Information
FGF family members have extensive mitogenic and cell survival properties and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.
Fibroblast growth factor 21 (FGF21) is a hepatocyte cytokine, a hormone secreted by the liver that regulates sugar intake and preference for sweets through FGF21 receptor signaling in the paraventricular nucleus of the hypothalamus. It is associated with decreased dopaminergic neurotransmission in the nucleus accumbens.
The function of Fgf21 is mainly in the aspects of glucose metabolism, lipid metabolism and insulin resistance. After specifically knocking out Fgf21 in the liver, the mice developed fatty liver and hyperlipidemia, and serum ketone body levels were lowered.
Gene symbol : Fgf21
Gene name : fibroblast growth factor 21
Gene IDs
MGI: 1861377
NCBI Gene: 56636
Location : located on mouse chromosome 7
application
To study the role of Fgf21 in the pathogenesis of metabolic diseases such as nonalcoholic fatty liver, obesity and diabetes.
Line status
Cryopreservation of sperm
technology
CRISPR/Cas9 Technology
Contact information
Contact number: 400-680-8038
E-mail:
Company website:
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