US study found that women's premature birth is associated with low cholesterol levels

Release date: 2007-11-20

US study found that women's premature birth and low cholesterol levels A study recently completed by US NIH scientists showed that pregnant women with very low cholesterol levels had a higher risk of preterm birth than women with higher cholesterol levels. [Pediatrics 2007, 120(4): 723] This study retrospectively analyzed 9,938 women in South Carolina who were screened for serological screening during the second trimester. Edison et al. classified the total cholesterol level in the serum to the 10th percentile (average 159 mg/dl at 17.76 weeks of gestation) as the “low total cholesterol” prenatal risk group. The women enrolled were 21 to 34 years old, no smoking, no diabetes, and the newborn was a single pregnancy. The total cholesterol value of each group was corrected for the number of gestational weeks at the time of screening before the risk grouping. The study population included 118 women with low total cholesterol levels and 940 women with high total cholesterol levels. The multiple regression models were used to analyze the above two groups, and the incidence of preterm birth, fetal growth index, and congenital malformation were compared.
The study showed that the preterm birth rate was 12.7% in the mothers with low total cholesterol levels and 5.0% in the moderate total cholesterol levels. Preterm birth is associated with low serum cholesterol levels only in white mothers. The full-term infants in the low total cholesterol level had a body weight that was 150 g lower than the control group. There is an increased risk of microcephaly in neonates with low total cholesterol levels. Low maternal serum cholesterol levels are not associated with the risk of other congenital malformations in the offspring. Research suggests that serum total cholesterol levels
——Midi Medical Network

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