Aphrodisiac Natural Kidney Sex Enhancement Epimedium Extract/ Icariin CAS 489-32-7

Aphrodisiac Natural Kidney Sex Enhancement Epimedium Extract Icariin
 

Product Description
Icariin
CAS No.: 489-32-7
Product Name: Horny goat weed extract/ Epimedium extract/Epimedium P.E
Latin Name: Epimedium grandiflorum L.
Plant source: Epimedium
Specification : 5:1,10:1,20:1  or accoding to your request. 
Ingredient: Icariin/Epinedoside A
Herb Source: Epimedium 
Content: Icariin 5%,10%,20%,50%,70%,90%
Formula: C33H40O15
Exact Mass: 676.237
Molecular Weight: 676.662
PSA: 238.2
LogP: 0.0679
Assay Method: HPLC
Appearance: Brown or yellow fine powder
Storage: Store in cool & dry place, and keep away from strong light and heat.
Shelf Time: 2 years when properly stored
Package: 25kg/drum, inner with double-layer plastic bags


Brief Introduction
 
Epimedium species are deciduous or evergreen hardy perennials. The majority have four-parted "spider-like" flowers in spring.
The plant contains icariin, which is a PDE5 inhibitor like sidenafill, the active ingredient of Vigra. It is therefore used as an aphrodisiac and a treatment for erectile dysfunction.
 Icariin 5%, 10%, 20%, 98%/ISO, SGS, Bureau Veritas, QS, FDA, KOSHER
 
 
Dear friends, just feel free to contact with us!
 
Whats.App: +8618188938027

If you want to find stable supplier with high quality, competitive price, safe delivery and best sales service,then I am your best choice.


 
Function:

1. Erectile dysfunction
 It is sold as a health supplement, usually in raw herb, tablet, or capsule form and sometimes blended with other supplements. The over-exploitation of wild populations of Epimedium for use in traditional Chinese medicine is having potentially serious consequences for the long-term survival of several species, none of which is widely cultivated for medicinal purposes.

Herbal epimedium contains icariin, which has demonstrated in vitro PDE5 inhibitory properties.
Icariin is purported to work by increasing levels of nitric oxide, which relax smooth muscle. It has been demonstrated to relax rabbit penile tissue by nitric oxide and PDE-5 activity. Other research has demonstrated that injections of Epimedium extract directly into the penis of the rat results in an increase in penile blood pressure.

Like sidenafill (the erectile dysfunction drug commonly sold as Vigra), icariin, the active compound in epimedium, inhibits the activity of PDE-5. In vitro assays have demonstrated that icariin weakly inhibits PDE-5 with an IC50 of around 1 μM, while sidenafill has an IC50 of about 6.6 nM (.0066 μM) and vardenafil has an IC50 of about 0.7 nM (.0007 μM). Measured differently, the EC50 of icariin is approximately 4.62 μM, while sidenafill's is .42 μM. With the weak potency of epimedium, and its unknown oral bioavailability, whether orally administered epidemium extract has any effect is unclear from the literature.

A published Italian study modified icariin structurally and investigated a number of derivatives. Inhibitory concentrations for PDE-5 close to could be reached. Moreover, the most potent PDE-5 inhibitor of this series was also found to be a less potent inhibitor of phosphodiesterase-6 (PDE-6) and cyclic adenosine monophosphate-phosphodiesterase (cAMP-PDE), thus showing it to have more specificity for PDE-5 than sidenafill.

Epimedium has been shown to up-regulate genes associated with nitric oxide production and changes in adenosine/guanine monophosphate balance in ways that other PDE5 inhibitors do not.
Epimedium was used in a patent infringement case to rescind parts of the U.S. Vigra patent based on historic use in Chinese medicine. The specific claim was that Vigra was the first medical example of a PDE5 inhibitor which treated erectile dysfunction and therefore claimed patent protection from all similar PDE5 inhibitors. Patent examiners used epimedium as an example of prior use and rescinded those portions of the patent, however, the patent still protects the manufacturing process or chemical formula for sidenafill.

2.Osteoporosis
 Animal, human, and in vitro studies indicate that icariin also stimulates osteoblast activity in bone tissue.

3. Chemistry
Epimedium wushanense contains a number of flavanoids. 37 compounds were characterized from the underground and aerial parts of the plant. Among them, 28 compounds were prenylflavonoids. The predominant flavonoid, epimedin C, ranged from 1.4 to 5.1% in aerial parts and 1.0 to 2.8% in underground parts.
  Aphrodisiac Natural Kidney Sex Enhancement Epimedium Extract Icariin
 

Product Description
Icariin
CAS No.: 489-32-7
Product Name: Horny goat weed extract/ Epimedium extract/Epimedium P.E
Latin Name: Epimedium grandiflorum L.
Plant source: Epimedium
Specification : 5:1,10:1,20:1  or accoding to your request. 
Ingredient: Icariin/Epinedoside A
Herb Source: Epimedium 
Content: Icariin 5%,10%,20%,50%,70%,90%
Formula: C33H40O15
Exact Mass: 676.237
Molecular Weight: 676.662
PSA: 238.2
LogP: 0.0679
Assay Method: HPLC
Appearance: Brown or yellow fine powder
Storage: Store in cool & dry place, and keep away from strong light and heat.
Shelf Time: 2 years when properly stored
Package: 25kg/drum, inner with double-layer plastic bags


Brief Introduction
 
Epimedium species are deciduous or evergreen hardy perennials. The majority have four-parted "spider-like" flowers in spring.
The plant contains icariin, which is a PDE5 inhibitor like sidenafill, the active ingredient of Vigra. It is therefore used as an aphrodisiac and a treatment for erectile dysfunction.
 Icariin 5%, 10%, 20%, 98%/ISO, SGS, Bureau Veritas, QS, FDA, KOSHER
 
 
Dear friends, just feel free to contact with us!
 
Whats.App: +8618188938027

If you want to find stable supplier with high quality, competitive price, safe delivery and best sales service,then I am your best choice.


 
Function:

1. Erectile dysfunction
 It is sold as a health supplement, usually in raw herb, tablet, or capsule form and sometimes blended with other supplements. The over-exploitation of wild populations of Epimedium for use in traditional Chinese medicine is having potentially serious consequences for the long-term survival of several species, none of which is widely cultivated for medicinal purposes.

Herbal epimedium contains icariin, which has demonstrated in vitro PDE5 inhibitory properties.
Icariin is purported to work by increasing levels of nitric oxide, which relax smooth muscle. It has been demonstrated to relax rabbit penile tissue by nitric oxide and PDE-5 activity. Other research has demonstrated that injections of Epimedium extract directly into the penis of the rat results in an increase in penile blood pressure.

Like sidenafill (the erectile dysfunction drug commonly sold as Vigra), icariin, the active compound in epimedium, inhibits the activity of PDE-5. In vitro assays have demonstrated that icariin weakly inhibits PDE-5 with an IC50 of around 1 μM, while sidenafill has an IC50 of about 6.6 nM (.0066 μM) and vardenafil has an IC50 of about 0.7 nM (.0007 μM). Measured differently, the EC50 of icariin is approximately 4.62 μM, while sidenafill's is .42 μM. With the weak potency of epimedium, and its unknown oral bioavailability, whether orally administered epidemium extract has any effect is unclear from the literature.

A published Italian study modified icariin structurally and investigated a number of derivatives. Inhibitory concentrations for PDE-5 close to could be reached. Moreover, the most potent PDE-5 inhibitor of this series was also found to be a less potent inhibitor of phosphodiesterase-6 (PDE-6) and cyclic adenosine monophosphate-phosphodiesterase (cAMP-PDE), thus showing it to have more specificity for PDE-5 than sidenafill.

Epimedium has been shown to up-regulate genes associated with nitric oxide production and changes in adenosine/guanine monophosphate balance in ways that other PDE5 inhibitors do not.
Epimedium was used in a patent infringement case to rescind parts of the U.S. Vigra patent based on historic use in Chinese medicine. The specific claim was that Vigra was the first medical example of a PDE5 inhibitor which treated erectile dysfunction and therefore claimed patent protection from all similar PDE5 inhibitors. Patent examiners used epimedium as an example of prior use and rescinded those portions of the patent, however, the patent still protects the manufacturing process or chemical formula for sidenafill.

2.Osteoporosis
 Animal, human, and in vitro studies indicate that icariin also stimulates osteoblast activity in bone tissue.

3. Chemistry
Epimedium wushanense contains a number of flavanoids. 37 compounds were characterized from the underground and aerial parts of the plant. Among them, 28 compounds were prenylflavonoids. The predominant flavonoid, epimedin C, ranged from 1.4 to 5.1% in aerial parts and 1.0 to 2.8% in underground parts.
 

Sorfa cell culture flasks (also named tissue culture flasks) are designed in three types of area for cell culture: 25 cm2, 75cm2 and 175cm2.The engraved graduation on one side of flask helps users to fill accurate volume of medium. Marking area is made to identify flasks for different purpose and ridges on the top make flask easy to stack. Sorfa angled design of neck is for pipette easy to access flask to touch each corner.

caps are categorized to plug seal cap and vent cap. Plug seal cap usually applies to airtight culture, however, it`s suitable for open culture when unscrewing cap. Vent cap is designed for open culture for it includes a hydrophobic membrane of 0.2 um. Membrane prevents gas from contaminating in the process of exchanging. It`s recommended to use CO2 incubator for vent cap, special for long-term cell culture.

For TC (Tissue Culture) surface treatment, flasks are available for suspension culture and adherent culture to meet global market need. All Sorfa tissue culture flasks are packaged in bags with sterilization, RNase-free, DNase-free and Non-pyrogenic.

Sorfa cell culture flasks (also named tissue culture flasks) are designed in three types of area for cell culture: 25 cm2, 75cm2 and 175cm2.The engraved graduation on one side of flask helps users to fill accurate volume of medium. Marking area is made to identify flasks for different purpose and ridges on the top make flask easy to stack. Sorfa angled design of neck is for pipette easy to access flask to touch each corner.

Caps are categorized to plug seal cap and vent cap. Plug seal cap usually applies to airtight culture, however, it`s suitable for open culture when unscrewing cap. Vent cap is designed for open culture for it includes a hydrophobic membrane of 0.2 um. Membrane prevents gas from contaminating in the process of exchanging. It`s recommended to use CO2 incubator for vent cap, special for long-term cell culture.

For TC (Tissue Culture) surface treatment, flasks are available for suspension culture and adherent culture to meet global market need. All Sorfa tissue culture flasks are packaged in bags with sterilization, RNase-free, DNase-free and Non-pyrogenic.

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