Cancer cells can achieve precise hunting in the future

Cancer cells can achieve precise hunting in the future

July 09, 2018 Source: China Youth Daily

How can I accurately find tumor cells and kill them? Recently, at the scientific and technological achievements conference held by Xi'an Jiaotong University, the results of the "Intelligent Controlled Release Materials" developed by Chen Xin, the director of the Institute of Polymer Chemicals, attracted the attention of all parties.

Chen Xin said that the successful development of this series of composite micro-nano controlled release materials can solve the precise treatment of tumors, infectious diseases, immune diseases and other diseases, and can also achieve efficient induction regeneration of bones, skin, teeth and other tissues.

As we all know, "chemotherapy" is currently one of the main means of treating cancer. However, traditional chemotherapy often "does not distinguish between the enemy and the enemy", and the drawbacks are obvious: its rapid treatment is limited to the surface tumor cells, but it cannot target deep tumor cells. Not only that, but because of the inability to find tumor cells autonomously, chemotherapy also kills a large number of normal cells.

"Intelligent controlled release materials research has always been regarded as an important development direction in the field of modern biomedicine." Chen Xin introduced how to achieve precise drug delivery that fully meets physiological needs through intelligent controlled release materials, which is a problem that plagues the clinical medical community.

"The intelligent controlled release material we developed is like an 'alarm clock' that controls drug release." It can control whether the drug is released and the speed and extent of release based on the response of the lesion environment.

For example, if the tumor is regarded as a target, the composite micro-nano controlled release material is like an "aircraft carrier". This "aircraft carrier" can carry many "weapons". These "weapons" include targeted drugs for treating tumors, tracers during treatment, and even visual devices.

Through the intelligent control of "aircraft" by "aircraft carrier", the release dose, release time and target of targeted drugs can reach a very precise level. "It can accurately kill tumor cells and inhibit without affecting healthy cells." tumor metastasis."

So how does the "aircraft carrier" do it? In fact, the structure of the "aircraft carrier" is the designed nano drug carrier and polymer gel structure system. The principle is to generate a gel structure around all tumor tissues. At this time, the electrophoresis carried by the gel structure can be absorbed by positive and negative ions to find the tumor tissue and release the anti-tumor drug.

Not only that, but after the implementation of the treatment, the pre-loaded stem cells on the "aircraft carrier" still have the potential to differentiate and regenerate. Because different cytokines are required at different stages of tissue regeneration, at the time of design, the research team uses sequence delivery to enable the "aircraft carrier" to release different cytokines in stages according to the needs of tissue regeneration. In this way, the "integration" of tumor treatment and tissue regeneration has also been realized.

In practice, Chen Xin team introduced advanced concepts such as chemotherapy, photothermal therapy, catalytic medicine, and targeted therapy into the treatment of oral cancer, achieving effective treatment and accurate labeling for oral cancer and other cancers, and inhibiting tumors for a long time. Recurrence significantly improved patient survival.

"This technology has the function of promoting tissue regeneration, and can also be used for the complete repair of large-area bones and skin defects." For example, cracks appear in the skull after the injury, in a block or fragment shape. At this time, smear or injection intelligent control Release the material and the skull can be completely repaired.

"This technology is also very practical in life." Chen Xin told reporters that it can carry "collagen" and so on, so that the mask becomes better absorbed and more efficient, and to a certain extent, it plays a role in delaying human aging. In the future, it can even lengthen tall bones for people with short stature by carrying "enhancement agents".

More than two years after the implementation of the project, 25 SCI papers have been published, and 5 Chinese invention patents have been applied for and approved. At present, some of the research results have been applied in cooperation with a number of hospitals and enterprises, covering medical, beauty, health care and other fields.

"In the next few years, this achievement is expected to enter mass production and application." Chen Xin said. (Reporter Sun Haihua)

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