Carl June publishes a big achievement: CAR-T treats solid tumors or "has a play"
In recent years, the results of CAR-T therapy in the treatment of malignant hematological tumors are obvious to all. However, the bottleneck for the treatment of solid tumors still makes many scientists "headache". To solve this problem, we need to consider the selection of target antigens, the management of toxicity, and the regulation of immunosuppressive tumor microenvironment. Recently, the "big cow" in the CAR-T field and Professor Carl H. June of the University of Pennsylvania have made the latest breakthrough in the resolution of solid tumors.
On June 21st, Cell's Immunity magazine (latest impact factor 24.082) published the latest study entitled "Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma", Carl H. June and Avery D. Posey Jr., a postdoctoral researcher at the laboratory, is the co-author of the study.
In the study, scientists used genetic engineering to engineer human T cells to produce a CAR that recognizes specific glycopeptides that are expressed in a variety of cancer cells but not in normal cells. The team demonstrated the effectiveness of this new CAR-T therapy in a mouse model of leukemia and pancreatic cancer.
Avery Posey, who is also the first author of the study, said: "This is the first method to target such cancer-specific glycoproteins (Glycoantigens) using the patient's own immune cells. This will have a wide range of cancer types. A huge advantage. In the future, combination immunotherapy targeting cancer-specific carbohydrates and cancer proteins is expected to provide patients with extremely effective and safe new treatments."
In recent clinical trials, CAR-T cell therapy has significantly improved the treatment outcome of patients with blood cancer, but the full potential of CAR-T for solid tumors has not been fully released, in part because its targeted molecules appear simultaneously in normal The surface of cells and cancer cells, causing serious side effects. In fact, some of the scientists involved in the study hope to find a solution quickly for very personal reasons. One of their colleagues who made a lifetime contribution to the field of cancer genetics was diagnosed with advanced cancer.
Laura Johnson, who participated in the study, said: "She knows our work and asks if we have any promising therapies to help her. This really has greatly motivated us." In the end, Johnson and her team identified cancer cells. A marker is a specific change in protein glycosylation, a unique pattern of cell surface sugar-modified proteins.
5E5 mAb and 5E5 CAR specifically Recognize the Tn-MUC1, but Not the Peptide Alone
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