Drug intervention for Alzheimer's disease

Drug intervention for Alzheimer's disease

January 11, 2018 Source: Science and Technology Daily

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"Science" magazine official website recently reported that British scientists first discovered that in the brain of patients with Alzheimer's disease (Alzheimer's disease), tau protein can spread from neurons to neurons. This finding suggests how this destructive disease can cause degenerative disease and provides new ideas for containing brain damage.

Both tau and amyloid beta form unusual plaques in the brains of Alzheimer's patients. Scientists have long debated which proteins are more important to the condition and thereby determine the best intervention goal. Ï„ deposits are found in neurons and are generally thought to be eliminated in neurons, while beta amyloid forms plaques outside the brain cells.

Researchers at the University of Cambridge scanned images of tau protein and brain functional regions in 17 Alzheimer's patients to study how spatially separated brain regions communicate with each other. They found that the region with the highest concentration of harmful tau protein was very tightly linked to other brain regions, suggesting that tau protein may be transmitted in a manner similar to influenza--the most exposed person is most susceptible to influenza infection. The team said the findings support an Alzheimer's hypothesis called "trans-neural transmission," which was previously confirmed in mice.

The new conclusions are very exciting, because the researchers can also prove that when the accumulation of tau protein is higher, the brain area as a whole has fewer connections, and the connections are more and more random. Nathan Sprenge, a neuroscientist at the Institute of Neurology and Hospital in Montreal, Canada, said the evidence for the spread of tau protein was "convincing."

The mechanism of tau protein transmission may have an impact on clinical treatment. If the drug can attack tau protein in the synapse outside the neuron, these harmful proteins can be locked and destroyed before infecting other nerve cells and spreading.

But George Sepulcori of Harvard Medical School in Boston, USA, pointed out that the conclusion of this study should be treated with caution because it “does not include time-based proof or verification of the nature of tau protein transmission, and the sample size is small”. However, the research team is now investigating more patients with Alzheimer's disease and tracking their changes over time through brain imaging. (Reporter Fang Linlin)

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