Dyclonine Pharmaceutical Raw Materials Dyclonine Hydrochloride

Pharmaceutical Raw Materials Dyclonine Hydrochloride CAS; 536-43-6

Quick detail;

Name;Dyclonine hydrochloride
Biology description;Sodium channel blocker. HSP90 chaperone protein inhibitor. Shows local anesthetic effects in vivo. Orally active.
Chemical Name;1-(4-Butoxyphenyl)-3-piperidin-1-ylpropan-1-one hydrochloride
CAS; 536-43-6
Molecular weight; 325.87
Formula; C18H27NO2.HCl
Solubility Overview; Soluble in water to 10 mM, in DMSO to 25 mM and in ethanol to 100 mM
 
Specifications:
  
Decriptions;  

Dyclonine Hydrochloride is the hydrochloride salt of Dyclonine, an unclassified compound with local anesthetic effect. Dyclonine reversibly binds to activated sodium channels on the neuronal membrane, thereby decreasing the neuronal membrane's permeability to sodium ions, leading to an increased threshold for excitation. This reversibly stabilizes the membrane and inhibits depolarization, leading to the failure of a propagated action potential and subsequent conduction blockade. This results in a transient and reversible loss of sensation in a localized area of the body.

User;

Dental procedure - Local anesthesia: 0.5% solution ORALLY as a spray or gargle
Local anesthesia: dosage varies and depends upon the area to be anesthetized, vascularity of the tissues, individual tolerance, and the technique of anesthesia
Local anesthesia: 4 to 20 mL of 1% spray TOPICALLY to accesible mucous membranes; MAX dose 300 mg; single dose MAX 200 mg
Local anesthesia: apply 0.5% solution TOPICALLY as wet compresses or as a spray to episiotomy or perineorrhaphy wounds
Local anesthesia: apply pledgets of cotton or sponges moistened with 0.5% solution TOPICALLY to postoperative wounds following proctology procedures
Pain in throat: one 2 to 3 mg lozenge ORALLY dissolved in mouth slowly every 2 h as needed
Pain in throat: 4 sprays of 0.1% spray ORALLY with swallow; may be used as gargle or rinse on the affected area for 15 sec and spit out 6 times a day as needed
Pharyngeal gag reflex finding: 0.5% solution ORALLY as mouthwash or gargle
Stomatitis: 5 to 15 mL of 0.5% solution ORALLY with swallow for lesions of the esophagus; as a rinse or swab applied to inflamed or ulcerated mucous membranes of the mouth Pharmaceutical Raw Materials Dyclonine Hydrochloride CAS; 536-43-6

Quick detail;

Name;Dyclonine hydrochloride
Biology description;Sodium channel blocker. HSP90 chaperone protein inhibitor. Shows local anesthetic effects in vivo. Orally active.
Chemical Name;1-(4-Butoxyphenyl)-3-piperidin-1-ylpropan-1-one hydrochloride
CAS; 536-43-6
Molecular weight; 325.87
Formula; C18H27NO2.HCl
Solubility Overview; Soluble in water to 10 mM, in DMSO to 25 mM and in ethanol to 100 mM
 
Specifications:
  
Decriptions;  

Dyclonine Hydrochloride is the hydrochloride salt of Dyclonine, an unclassified compound with local anesthetic effect. Dyclonine reversibly binds to activated sodium channels on the neuronal membrane, thereby decreasing the neuronal membrane's permeability to sodium ions, leading to an increased threshold for excitation. This reversibly stabilizes the membrane and inhibits depolarization, leading to the failure of a propagated action potential and subsequent conduction blockade. This results in a transient and reversible loss of sensation in a localized area of the body.

User;

Dental procedure - Local anesthesia: 0.5% solution ORALLY as a spray or gargle
Local anesthesia: dosage varies and depends upon the area to be anesthetized, vascularity of the tissues, individual tolerance, and the technique of anesthesia
Local anesthesia: 4 to 20 mL of 1% spray TOPICALLY to accesible mucous membranes; MAX dose 300 mg; single dose MAX 200 mg
Local anesthesia: apply 0.5% solution TOPICALLY as wet compresses or as a spray to episiotomy or perineorrhaphy wounds
Local anesthesia: apply pledgets of cotton or sponges moistened with 0.5% solution TOPICALLY to postoperative wounds following proctology procedures
Pain in throat: one 2 to 3 mg lozenge ORALLY dissolved in mouth slowly every 2 h as needed
Pain in throat: 4 sprays of 0.1% spray ORALLY with swallow; may be used as gargle or rinse on the affected area for 15 sec and spit out 6 times a day as needed
Pharyngeal gag reflex finding: 0.5% solution ORALLY as mouthwash or gargle
Stomatitis: 5 to 15 mL of 0.5% solution ORALLY with swallow for lesions of the esophagus; as a rinse or swab applied to inflamed or ulcerated mucous membranes of the mouth

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