High Quality and &Purity CAS 109581-93-3 Tacrolimus with Competitive Price
Brief Introduction:
Â
| Product name: | Tacrolimus |
| Synonyms: | Tsukubaenolide hydrate |
| CAS Registry Number: | 109581-93-3,104987-11-3 |
| Molecular Formula: | C44H69NO12 |
| Molecular Weight: | 804.02 |
| Appearance: | White to light yellow crystal powder |
| Purity: | 99% |
| Grade: | Pharmaceutical Grade |
Tacrolimus is an immunosuppressive drug used mainly after allogeneic organ transplant to lower the risk of organ rejection. It achieves this by inhibiting the production of interleukin-2, a molecule that promotes the development and proliferation of T cells, which are vital to the body's learned (or adaptive) immune response. Tacrolimus is also used in the treatment of other T cell-mediated diseases such as eczema (for which it is applied to the skin in a medicated ointment), severe refractory uveitis after bone marrow transplants, exacerbations of minimal change disease, Kimura's disease and the skin condition vitiligo.
Immunosuppression following transplantation
It has similar immunosuppressive properties to ciclosporin, but is much more potent. Immunosuppression with tacrolimus was associated with a significantly lower rate of acute rejection compared with ciclosporin-based immunosuppression (30.7% vs 46.4%) in one study.[8] Clinical outcome is better with tacrolimus than with ciclosporin during the first year of liver transplantation.[10][11] Long-term outcome has not been improved to the same extent. Tacrolimus is normally prescribed as part of a post-transplant cocktail including steroids, mycophenolate, and IL-2 receptor inhibitors. Dosages are titrated to target blood levels. Typical starting doses for once-daily tacrolimus are 0.15-0.20 mg/kg body weight.
Interactions
Also like ciclosporin, it has a wide range of interactions, including that with grapefruit which increases plasma-tacrolimus concentration. Several of the newer classes of antifungals, especially of the azole class (fluconazole, posaconazole) also increase drug levels by competing for degradative enzymes.
Ulcerative colitis
In recent years, tacrolimus has been used to suppress the inflammation associated with ulcerative colitis (UC), a form of inflammatory bowel disease. Although almost exclusively used in trial cases only, tacrolimus has shown to be significantly effective in the suppression of outbreaks of UC.
Dermatological use
As an ointment, tacrolimus is used in the treatment of eczema, in particular atopic dermatitis. It suppresses inflammation in a similar way to steroids, and is equally as effective as a mid-potency steroid. An important advantage of tacrolimus is that, unlike steroids, it does not cause skin thinning (atrophy), or other steroid related side effects.
It is applied on the active lesions until they heal off, but may also be used continuously in low doses (twice a week), and applied to the thinner skin over the face and eyelids.[citation needed] Clinical trials of up to one year have been conducted. Recently it has also been used to treat segmental vitiligo in children, especially in areas on the face.
Product Packaging
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag),or as required.
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery
Usually within 3-7 working days after payment.
Shipping
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;Â
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Service
we will try our best to satisfied you.
1. Tailor-made for every customers.Â
2. Third-party test for the products you demand.Â
3. Test your counter-samples and produce them for you.Â
4. Best discount for old customers.Â
5. Reasonable &Â competitive price, fast lead time.
6. Sample is available for your evaluation &Â Formulation development.
7. Faster delivery:Sample order in stock and 3-7 days for bulk production.
8.We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder
9. All inquiries will be replied within 12 hours.
10. Dedication to quality, supply &Â service.
11. Strictly on selecting raw materials.
After-Sale Service
1) International Authorized Third-Party Test For The Products You Demand.
2) 30 Days Warranty of quality of goods.
Â
The quality control process
1)Purchasing
Thorough market research, understand the price of raw materials and performance.To the procurement source to understand fully, and fully guarantee the quality of the procurement of raw materials.
2) Inspection
Four steps: sampling, sample pretreatment, measuring and data processing.
3) Producing
a)Each operator must do self-inspection of products and make the corresponding inspection records.
b)Full-time inspectors through check the operator self-inspection, and review and sign in the corresponding record. Full-time inspection is responsible for inspection of finished product, and make the finished product incoming inspection records.
4) Before sellingÂ
Test result can be provided before selling.
Third-party detection institution is allowed if you are not satisfied with test results.
Process and Advice:
Â
| Make an order | Please make clear what product and what quantity you need |
| Quote | Prices and Specifications details would be offered for you to consider and confirm |
| Payment ways | Bank Transfer, Western Union, Money Gram and Bitcoin |
| Delivery ways | All Express Modes(EMS, DHL, TNT, FedEx, UPS, etc.) |
| Shipping address | Provide your Valid and Correct destination address info(if possible with post code, phone number). |
| Packing | Select best ways according to quantity and safety degree(Super discreet, professional and experienced) |
| Lead time | Within 8 hours upon receipt of payment |
| Package picture | Photos of package would be offered to tell apart the items |
| Tracking number | Offered once it is released |
| Shipping time | 3-7 working days (Door-to-Door) |
| After-sale service | 24/7 Online for any problems |
Our Advantages
1. Rich experience:Our company is a professional production leading factory in China in pharmaceutical area of many years.Â
2. Discreet package :The packing suits you best would be choosen to cross customs safely. Or if you have your own ideal way, it could be also taken into consideration .
3. Top quality. High quality guaranteed, once any problem is found, the package would be reshipped for you .
4. Security Shipping:Shipping by express (FedEx,UPS,DHL,EMS), by air.The most professional forwarder would be recommanded for you.
5. Fast delivery:we have stock, so we can delivery quickly once payment is received.
6. Quality service:we will give you warm after-sale service,if any question we will reply you within 24 hours.
7. Competitive prices:A discount would be given when you make a large order.
Please feel free to contact me if you need any further information~
 High Quality and &Purity CAS 109581-93-3 Tacrolimus with Competitive Price
Brief Introduction:
Â
| Product name: | Tacrolimus |
| Synonyms: | Tsukubaenolide hydrate |
| CAS Registry Number: | 109581-93-3,104987-11-3 |
| Molecular Formula: | C44H69NO12 |
| Molecular Weight: | 804.02 |
| Appearance: | White to light yellow crystal powder |
| Purity: | 99% |
| Grade: | Pharmaceutical Grade |
Tacrolimus is an immunosuppressive drug used mainly after allogeneic organ transplant to lower the risk of organ rejection. It achieves this by inhibiting the production of interleukin-2, a molecule that promotes the development and proliferation of T cells, which are vital to the body's learned (or adaptive) immune response. Tacrolimus is also used in the treatment of other T cell-mediated diseases such as eczema (for which it is applied to the skin in a medicated ointment), severe refractory uveitis after bone marrow transplants, exacerbations of minimal change disease, Kimura's disease and the skin condition vitiligo.
Immunosuppression following transplantation
It has similar immunosuppressive properties to ciclosporin, but is much more potent. Immunosuppression with tacrolimus was associated with a significantly lower rate of acute rejection compared with ciclosporin-based immunosuppression (30.7% vs 46.4%) in one study.[8] Clinical outcome is better with tacrolimus than with ciclosporin during the first year of liver transplantation.[10][11] Long-term outcome has not been improved to the same extent. Tacrolimus is normally prescribed as part of a post-transplant cocktail including steroids, mycophenolate, and IL-2 receptor inhibitors. Dosages are titrated to target blood levels. Typical starting doses for once-daily tacrolimus are 0.15-0.20 mg/kg body weight.
Interactions
Also like ciclosporin, it has a wide range of interactions, including that with grapefruit which increases plasma-tacrolimus concentration. Several of the newer classes of antifungals, especially of the azole class (fluconazole, posaconazole) also increase drug levels by competing for degradative enzymes.
Ulcerative colitis
In recent years, tacrolimus has been used to suppress the inflammation associated with ulcerative colitis (UC), a form of inflammatory bowel disease. Although almost exclusively used in trial cases only, tacrolimus has shown to be significantly effective in the suppression of outbreaks of UC.
Dermatological use
As an ointment, tacrolimus is used in the treatment of eczema, in particular atopic dermatitis. It suppresses inflammation in a similar way to steroids, and is equally as effective as a mid-potency steroid. An important advantage of tacrolimus is that, unlike steroids, it does not cause skin thinning (atrophy), or other steroid related side effects.
It is applied on the active lesions until they heal off, but may also be used continuously in low doses (twice a week), and applied to the thinner skin over the face and eyelids.[citation needed] Clinical trials of up to one year have been conducted. Recently it has also been used to treat segmental vitiligo in children, especially in areas on the face.
Product Packaging
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag),or as required.
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery
Usually within 3-7 working days after payment.
Shipping
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;Â
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Service
we will try our best to satisfied you.
1. Tailor-made for every customers.Â
2. Third-party test for the products you demand.Â
3. Test your counter-samples and produce them for you.Â
4. Best discount for old customers.Â
5. Reasonable &Â competitive price, fast lead time.
6. Sample is available for your evaluation &Â Formulation development.
7. Faster delivery:Sample order in stock and 3-7 days for bulk production.
8.We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder
9. All inquiries will be replied within 12 hours.
10. Dedication to quality, supply &Â service.
11. Strictly on selecting raw materials.
After-Sale Service
1) International Authorized Third-Party Test For The Products You Demand.
2) 30 Days Warranty of quality of goods.
Â
The quality control process
1)Purchasing
Thorough market research, understand the price of raw materials and performance.To the procurement source to understand fully, and fully guarantee the quality of the procurement of raw materials.
2) Inspection
Four steps: sampling, sample pretreatment, measuring and data processing.
3) Producing
a)Each operator must do self-inspection of products and make the corresponding inspection records.
b)Full-time inspectors through check the operator self-inspection, and review and sign in the corresponding record. Full-time inspection is responsible for inspection of finished product, and make the finished product incoming inspection records.
4) Before sellingÂ
Test result can be provided before selling.
Third-party detection institution is allowed if you are not satisfied with test results.
Process and Advice:
Â
| Make an order | Please make clear what product and what quantity you need |
| Quote | Prices and Specifications details would be offered for you to consider and confirm |
| Payment ways | Bank Transfer, Western Union, Money Gram and Bitcoin |
| Delivery ways | All Express Modes(EMS, DHL, TNT, FedEx, UPS, etc.) |
| Shipping address | Provide your Valid and Correct destination address info(if possible with post code, phone number). |
| Packing | Select best ways according to quantity and safety degree(Super discreet, professional and experienced) |
| Lead time | Within 8 hours upon receipt of payment |
| Package picture | Photos of package would be offered to tell apart the items |
| Tracking number | Offered once it is released |
| Shipping time | 3-7 working days (Door-to-Door) |
| After-sale service | 24/7 Online for any problems |
Our Advantages
1. Rich experience:Our company is a professional production leading factory in China in pharmaceutical area of many years.Â
2. Discreet package :The packing suits you best would be choosen to cross customs safely. Or if you have your own ideal way, it could be also taken into consideration .
3. Top quality. High quality guaranteed, once any problem is found, the package would be reshipped for you .
4. Security Shipping:Shipping by express (FedEx,UPS,DHL,EMS), by air.The most professional forwarder would be recommanded for you.
5. Fast delivery:we have stock, so we can delivery quickly once payment is received.
6. Quality service:we will give you warm after-sale service,if any question we will reply you within 24 hours.
7. Competitive prices:A discount would be given when you make a large order.
Please feel free to contact me if you need any further information~
Â
Closed suction catheter,closed suction,closed suction set,closed suction tracheostomy
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