CELL: Father's high-sugar diet can lead to obesity in offspring
Release date: 2014-12-09
A new study suggests that the addition of carbohydrates to the diet of male fruit flies within 1 or 2 days prior to mating can affect the expression of embryonic gene expression, leading to obesity in Drosophila progeny.
There is evidence that similar biological systems that regulate susceptibility to obesity are also present in mice and humans. The study, published in Cell, brings new insights into how certain metabolic traits can be inherited and may help investigators determine if they can change.
Studies have shown that various factors that are transmitted (inherited) by parents or present in the uterine environment can influence the metabolism and body type of offspring. Researcher Dr. J. Andrew Pospisilik tried to understand whether parental dietary fluctuations might affect the next generation.
Through fruit fly mating experiments, scientists have found that intervention in the male diet may alter the structural components of the offspring, and increased sugar in the diet can lead to the next generation of obesity in fruit flies. High-glycemic diets increase gene expression through epigenetic changes, thereby affecting gene activity, but do not alter the underlying sequence of DNA.
Just like a computer, if our genes are hardware, our epigenetics is the software that determines how the hardware is used. Dr. OST explained that it turns out that the father's diet will reprogram epigenetics and generate the genes needed for fat. Will open in the next generation of fruit fly.
Since the epigenetic program is somewhat plastic, the researchers suspect that it is possible to reprogram the obese epigenetic program into a wasted epigenetic program. Currently, we and other researchers are manipulating epigenetics in the early stages of Drosophila life, but we don't know if it is possible to rewrite an adult epigenetic program.
The fruit fly model is a valuable resource for scientific research. Because flies breed fast, they allow researchers to quickly gain access to how nutrition and other environmental stimuli affect epigenetic details and whether they can be regulated early and late in Drosophila life.
Source: Bio Valley
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