Chinese scholars have discovered that the "attack and defense mechanism" of low temperature plasma killing cancer cells
Chinese scholars have discovered that the "attack and defense mechanism" of low temperature plasma killing cancer cells
October 25, 2018 Source: Xinhuanet
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Plasma is considered to be the "fourth state" of the existence of substances other than solids, liquids, and gases, and has shown broad application prospects in the biomedical field in recent years. Recently, the Hefei Institute of Material Science of the Chinese Academy of Sciences has made new progress in the treatment of tumors by atmospheric pressure and low temperature plasma. It has discovered the mechanism of plasma killing cancer cells and the "resistance" mechanism of cancer cells. It is important to predict and improve the efficacy of cancer prevention. Guiding significance. The international academic journal "Biochemistry and Physics Collection" recently published the results.
Recently, Han Wei, a researcher at the Center for Medical Physics and Technology of the Hefei Institute of Material Science, Chinese Academy of Sciences, found that plasma treatment “induced†the production of a large number of oxidative free radicals in cancer cells, destroying biological macromolecules in cells, leading to cancer cell death.
Their further research found that oxidative free radicals are also a "double-edged sword", which also activates the antioxidant signaling pathways such as heme oxygenase-1 in cancer cells, "helping" cancer cells to defend against plasma damage, thereby reducing efficacy. . The higher the background level of heme oxygenase-1 protein in lung cancer cells, the worse the killing effect of plasma.
"According to the results of this study, the protein background level of heme oxygenase-1 in cancer cells can be detected before clinical treatment to predict the efficacy of plasma." Researcher Han Wei said that if the content is high, it can pass Inhibit its "activity" and enhance the anti-cancer effect.
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