Geriatric depression accelerates its brain dementia
Release date: 2014-08-14
Recently, a study by the University of Pittsburgh School of Medicine showed that people who suffer from depression and mild cognitive impairment after 65 years of age are more susceptible to aging. The study was published in the journal Molecular Psychiatry on August 5.
Older people with severe depression are twice as likely to have dementia as controls, but there is no clear explanation for why emotional disorders such as depression can increase the risk of dementia. Dementia is a constantly changing brain disease. Until recently, most studies have only used one or two biomarkers to explain this problem.
The team collected blood samples from 80 elderly patients with major depression, including 36 with mild cognitive impairment and 44 with normal cognitive function. The experiment examined 242 proteins in blood samples, including tumors, cardiovascular diseases, and metabolic-related biosignal pathways, such as mental and neurodegenerative diseases. The researchers also performed PET scans and MRI scans of the subject's brain to look for indicators of cerebrovascular disease such as brain atrophy, as well as Alzheimer's disease brain plaque β-amyloid. The results showed that the biological activities of the 24 proteins in the group of subjects with mild cognitive impairment were different, involving immune regulation and inflammatory pathways, extracellular signaling pathways, cell survival and protein lipid balance. Brain scans for mild cognitive impairment are more likely to have cerebrovascular disease, such as stroke, but there is no difference in beta-amyloid deposition. Taken together, people with depression and cognitive impairment are more susceptible to brain aging and accelerate dementia.
This study provides a more complete view of neurobiological functional changes in advanced mild cognitive impairment-related diseases. A better understanding of the neurobiology of cognitive impairment in depression can provide new targets for more specific treatments, not only to prevent and treat depression, but also to prevent the development of dementia. The researchers said that the next step is to evaluate the normal cognitive function protein map of older people without depression.
Source: Life Science Research Express
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