How to improve the skin penetration of cosmetic active agents?
How to improve the skin penetration of cosmetic active agents?
-- Germany's ART's only nano-scale rotor technology
Germany ART is the only brand in the world that can adopt the stator-rotor technology to reach the nano-level, which greatly meets the high-precision needs of the pharmaceutical, cosmetics, fine chemical and other industries. So how does the German ART use this innovative technology to improve the skin permeability of cosmetic active agents?
Background: Conventional penetration enhancers can damage the skin and fail to meet FDA requirements
The skin is the outermost layer of the body, it protects the body from external factors such as pathogens, and avoids excessive water loss from the body. Therefore, healthy skin is an effective barrier to chemical penetration. The active agent of cosmetics is chemically unstable, insoluble, low in osmosis and low in biological activity. So the purpose of modern cosmetic formulations is to study how to deliver the active agent into the skin.
One way to improve delivery of the active agent is to use a penetration enhancer such as ethanol. The principle of these penetration improvers is that they interact with the skin barrier, which in turn changes the structure of the skin. This method is effective, but it can damage the skin, so we should try to avoid this method for cosmetic care products.
According to the requirements of the FDA, modern cosmetics should cleanse the skin and beautify the personal image without changing the human body structure.
Can improve the skin permeability of the active agent without damaging the skin, or even the characteristics of skin care, how to achieve? Nanocarriers are the best choice!
As can be seen from the above two figures, the carrier form of the nanoparticles is easier to achieve skin penetration, and the nanocarriers refer to submicron and nanoscale particles. The nanocarriers are characterized by: 1) small volume; 2) the target is directed against the skin hair follicle. This is the latest concept in the field of cosmetics and even medicine.
For example: liposomes, nanoemulsions, lipid nanoparticles (SLN and NLC), and nanocrystals (smartCrystals, ARTcrystals).
The properties of these carriers are different, such as: liposome is most suitable for the transport of hydrophilic active agents, nanoemulsions and lipid nanoparticles are most suitable as lipophilic active agent carriers, nanocrystals are most suitable for poorly soluble compounds.
How to produce nano carriers and nano cosmetics? -- Using ART Nanotechnology
The most important point in the application of this innovative concept is how to make this formulation possible on a large scale, while saving both time and cost.
Cosmetic nanocarriers can be produced using a high pressure dispersion homogenizer (HPH) and a ball mill (BM). However, the high-pressure homogenizer and the ball mill are large in size, high in energy consumption, long in processing time, and large in investment.
The latest high-precision stator-rotor system from ART-MICCRA in Germany is particularly effective for the production of cosmetic nanocarriers. The D-27 is an online decentralized system that can work continuously for 24 hours. The latest technology of water-cooled motors, with its ultra-high speed (36,000RPM) and powerful motor power (2,700W), combined with ultra-precision stator and rotor, achieves the world's unique nano-processing effect, and only 63 decibels low noise.
Highly efficient processing equipment will make it possible to use nanocarriers to improve the skin permeability of the active agent. This applies not only to high-priced luxury cosmetics, but also to general care products.
If the nanocarrier and the cosmetic cream are further dispersed and emulsified, a nano cosmetic can be obtained.
In summary, the insoluble or bioactive agents that were previously ineffective for the skin, such as flavonoids, now take cosmetic actives to a new level because of nanocrystal technology; while ART – MICCRA also allows cosmetic nanocarriers. The economic and efficient production has entered a new milestone.
(Edited in this article, taken from Dr. Cornelia Keck, Germany. Dr. Cornelia Keck is Professor of Pharmacology and Pharmacy at the University of Applied Sciences Kaiserslautern; Lifetime Science Advisor, ART, Germany)
About Ubi and British Bibby / German ART / German CAT ( http://bibbyyt.instrument.com.cn . Phone/Fax: 020 2802 3589; Email: )
Guangzhou Special Instrument Technology Co., Ltd. specializes in general instruments such as laboratory sample preparation such as agitator/dispersive emulsifier, analytical instruments such as melting point/photometer, and life science instruments such as PCR. As the first generation of British Bibi in South China, Guangdong, Guangxi, Sichuan, Chongqing, Yunnan, Hainan, Guizhou and Tibet are our services. The company is also the German ART, the first generation of German CAT in China.
British BIBBY was founded in the 1950s as one of the UK's largest manufacturers of laboratory scientific instruments, one of the world's most extensive range of laboratory instrument manufacturers, offering high quality and high operation to branded products worldwide. Known for its performance. It has 4 sub-brands: Stuart, Techne, Jenway, Electrothermal.
ï¬ Â· Stuart: Specialized laboratory instruments such as sample pretreatment, including: melting point meter, colony counter, agitator, mixer, shaker, pure water distiller series;
ï¬ Â·Techne: Focus on molecular biology research equipment (gene amplification equipment and hybridization boxes), as well as temperature control product lines (including water baths and dry baths);
ï¬ Â·Jenway: An expert in analytical instruments such as UV/Spectrophotometer, Flame Photometer, and Colorimeter;
ï¬ Â·Electrothermal: As a new member of BIBBY with more than 70 years of history, the world's leading scientific instrument provider, providing electric heating sets, parallel reaction equipment, Kjeldahl nitrogen equipment, electronic Bunsen burner series. Its parallel reaction equipment is the global market leader.
Founded in the last century, Germany ART is the most professional dispersing emulsifier in Germany and the world. Its top-grade dispersing emulsified products range from laboratory instruments to pilot products to industrial equipment. There are many types of dispersing heads to meet customers' various needs. The application fields cover chemical, cosmetic, pharmaceutical, food, environmental protection and other fields.
Founded in the 1950s, CAT Germany is one of the experts in German sample preparation instruments. Its agitator, from hand-held, teaching, to scientific research, high-viscosity type, is the representative product line of CAT; nowadays it is led by the ordinary electronic motor to the brushless motor, leading the development trend of the mixer.
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