Naked moles provide new clues to human anti-aging
Naked moles provide new clues to human anti-aging
August 7, 2018 Source: Xinhua Author: Zhang Jiawei
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];The naked moles with little hairs always bring new surprises to scientists. A study published in the British journal Biomedical Center Biology on the 2nd said that the breeding ability of naked squirrels lived longer than the working mice, which is contrary to the traditional perception of mammalian reproductive and life conditions. Human anti-aging research provides new clues.
The naked mole mouse mainly lives in Africa and is a mammal with a small body and almost no body hair. Scientists have discovered that this cold-blooded mammal has lived for decades more than other rodents, has almost no cancer, is not afraid of pain, and can survive for a long time in an anaerobic environment.
The naked mole group usually consists of 2 reproductive-only leaders and approximately 300 non-reproductive workers. Researchers at the Leibniz Institute for the Elderly in Germany have observed that the leader of the nude mole group has a longer life span than the worker and maintains reproductive capacity throughout life, which is expected to cause additional energy consumption and reduced life expectancy. completely different.
According to Martin Bens, author of the paper and Leibniz Institute for the Elderly, our research shows that when naked squirrels mature and reproduce, their aging rate changes, causing the leader to live longer than the worker. This is surprising, as evidence from other species suggests that reproduction, while beneficial to the survival of the entire species, reduces individual lifespan, but in nude moles, reproduction seems to extend life.
Further analysis showed that the expression of senescence-related genes in the nude mice with reproductive ability was significantly different from that of the rats, the guinea pigs with reproductive ability and the guinea pigs without reproduction ability. Guinea pigs are close relatives of naked mole rats but have a short life span.
In addition, unlike the non-reproductive guinea pigs or other rodents, there is no difference in body type, body weight or external genitalia between the male and female rats of the non-reproductive ability, and the difference in behavior is also small, that is, there is no such thing. Gender dimorphism. However, once the female naked moles resume their reproductive capacity, their physiology and behavior also change, and the expression levels of longevity and health-related genes also change.
The researchers believe that the in-depth exploration of the naked mole mouse genome will help us better understand the regulatory mechanisms of human sexual maturity. “Different people have different puberty onsets, which are affected by many factors such as stress and nutrition. At the same time, the onset of puberty affects the risk of many diseases such as breast cancer and cardiovascular disease. Our research may help to find Reducing the target of this difference," Bens said.
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