American researchers have for the first time cultivated transgenic yeasts that produce human glycoproteins

Yeast plays an important role in the fields of beer brewing and food processing. Dartmouth College scientists have recently found a new "work" for yeast: to produce therapeutic human glycoproteins. Scientists reported in a new issue of the American Journal of Science that they first cleared yeast glycoprotein production “channels” in the yeast and then added 5 human genes to the yeast. This yeast can then pass a series of Steps to synthesize human glycoproteins. Scientists described that they successfully achieved the "humanization" of yeast. Professor Glenn Gross, who participated in the research, pointed out that the new results "for the first time proved that yeast can be used to produce complex human glycoproteins." This technology is expected to make the production of medical human proteins "better quality, lower cost and faster." Faster and safer." With the help of genetically modified bacteria, etc., to produce human proteins and use them for disease prevention and control, an increasingly large market is being formed. The vast majority of medical human proteins are accompanied by sugar molecules that determine the folding shape and function of proteins. Immune cells also identify host proteins and foreign invaders through sugar molecules. Mammalian cell lines have traditionally been used to synthesize medical human glycoproteins, but this method has low yields, long production cycles, and is prone to viral infections. Scientists said that genetically modified yeast can effectively solve these problems. It can reduce the time to manufacture glycoproteins from the original two or three weeks to three or four days, and production can also be greatly increased.

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