Clinical application of Mao Dongqing
Clinical application
1 treatment of coronary atherosclerotic heart disease
Mao Dongqing has a good effect on angina, but the efficiency is not consistent, ranging from 68 to 96% (the number of cases are in 100 cases up and down), of which significantly higher efficiency of about 50%, only 10.3% of the low. The vast majority of effective cases showed a marked improvement in symptoms within 1 month after treatment. After 3 months, a small number of patients had repeated, but most of them had lessened than before. The effects on heart function, heart rate, blood pressure, and serum cholesterol were also not consistent. In some regions, most patients have been treated for about 1 month, their cardiac function has improved to varying degrees, serum cholesterol has decreased, blood pressure has decreased to a certain extent, and it has a certain effect on arrhythmia. Some people think that Mao Dongqing's treatment of myocardial infarction may have the effect of stopping the ectopic rhythm of the heart, reducing or eliminating heart rhythm disorders, maintaining the normal rhythm of the heart, maintaining a good level of blood output from the heart, thereby maintaining good blood pressure, and preventing shock and heart. The failure occurs. However, there have been no observations that have had a significant impact on the above items. After treatment, the electrocardiograms in some cases returned to normal or improved, but the effective rate was only 20.5%, and the high was 80.2%. The change of electrocardiogram was not consistent with the improvement of symptoms. According to analysis of electrocardiograms before and after treatment of effective cases, it was also suggested that Mao Dongqing may not be ideal or have a slower effect in improving coronary circulation. Most patients had clinical symptoms such as chest pain, headache, dizziness, and numbness in the limbs disappeared or significantly improved after taking the medicine; however, the relationship between the efficacy and the severity of the disease did not seem to be large. According to the type of traditional Chinese medicine, qi and yin deficiency are less effective. The use of Mao Dongqing alone is slow, and the addition of new acupuncture therapy can take effect earlier, and it can strengthen the effect of eliminating or relieving pain. Oral treatment of myocardial infarction with Mao Dongqing, although there is pain relief, but it can not replace morphine; therefore, patients with myocardial infarction often need to be in accordance with the needs of the condition, combined with western medicine treatment.
Dosage and usage: A decoction: Mao Dongqing root 3 to 5 two, one daily, decoction three times serving; or with tablets, granules, syrups, etc., the dose according to the daily crude drug 3 to 4 two calculations, 3 sub-services. Two injections: Formulation specifications are not uniform throughout. Injectables used in the Guangzhou area were 8 grams of each crude drug, or 20 mg of purified flavonoids. Intramuscular injection, 2 times a day, one at a time. Maodongqing injection used in Beijing and Fuzhou, each containing 40 mg of flavonoids (equivalent to 8 grams of crude drug), intramuscularly, once daily, one at a time. Another type of injection containing 0.5% of docanoside extract, intramuscular injection of 2 ml each time, 2 times a day; for intravenous drip, use 20 ml each time, plus 10% glucose solution 100-200 ml dilution , once a day. Injections used in the Tianjin area also have two specifications. One is to purify the hollywine preparation, 40 to 80 mg per day, divided into two injections; one is a 200% tonque injection, 4 ml per day, divided into two injections. In the treatment, oral preparations or injections were used alone, and they were also used in combination. According to clinical observations, all dosage forms have therapeutic effects, but oral administration is not as good as adding injections. It is best to start oral and intramuscular injections. Individual cases receive good results after intravenous infusion. The treatment time is generally 6 to 8 weeks or 1 to 3 months as a course of treatment. After the end of one course of treatment, the second course of treatment was stopped after two weeks. Experience has shown that those who take the medication for 4 weeks are still effective if they continue to take more than half of the medication, and those who do not continue to take the medication will still be invalid. Some people think that after obtaining the curative effect (usually 1 to 3 months), you can stop the medicine observation, re-use the medicine when it is repeated, or use the medicine intermittently for several months, that is, use it for 20 days per month and stop the medicine for 10 days.
No serious side effects were found during the medication. A few cases showed prolonged clotting time and prothrombin time, some bleeding tendency, such as nosebleeds, gingival bleeding, skin ecchymosis, delirium, increased menstrual flow, fecal occult blood and so on. After oral administration of Mao Dongqing, some patients experienced bloating, loss of appetite, dry mouth, or nausea and vomiting, and dry or thin stools. Once treated with bald hair holly in 31 cases, after 1 to 2 months of observation, the total effective rate was 64.5%, and the markedly effective rate was 35.5%. In order to control angina, the effect was faster and more obvious. Of the 26 cases, 17 cases were markedly effective, most of them disappeared or almost disappeared in 3 to 5 weeks, and the other 9 cases also improved. In addition, after treatment, heart function was improved to varying degrees in most cases, and the tolerable doses of physical labor and daily activities were all enhanced; blood pressure below 180/100 mm Hg was slightly lower in some cases and blood pressure was higher. There was no antihypertensive effect; there was a slight decrease in cholesterol, phospholipids, and triglyceride in 20% of cases. The recovery of ECG is slower than the improvement of symptoms and the effect is also poor. Usage: bald holly injection, intramuscular injection, daily 4 ml (containing 40 mg of flavonoids). 1 month for a course of treatment, the middle can be suspended for 3 to 5 days.
2 treatment of cerebral thrombosis
The daily use of Mao Dongqing 2 to 3 two decoction, and if appropriate, plus Mao Dongqing injection. Western medicine vasodilators should be properly applied at the stage of disease progression. After stable disease, they should be gradually phased out. Individuals should be treated with new acupuncture. Six cases have been observed. The shortest effective days after administration are 4 days, the longest is 16 days, and the shortest cure date is 13 Days, the longest 52 days. It is believed that Mao Dongqing can shorten the course of treatment and make the recovery of the body more complete. However, Mao Dongqing can only play a role in relieving snoring, thereby improving the role of blood supply (oxygen) in brain tissue and cannot replace the exercise and recovery of brain cell function. In addition, the treatment of cerebrovascular accident sequelae with oral combination of Mao Dongqing and acupoint catgut embedding has certain effects.
Oral Mao Dongqing syrup (containing 500 grams of crude drug per 100 ml), 20 ml each time, 3 times daily. 23 cases were observed. The results were markedly improved in 10 cases, the symptoms and signs were significantly improved, and laboratory tests were also changed. In addition, 11 cases had some improvement in symptoms and signs, but there was no major change in laboratory tests.
3 treatment of thromboangiitis obliterans
According to the analysis of 319 cases, the effective rate was 80.2%, of which cure rate accounted for 28.8% and significant improvement was 18.8%. According to preliminary observations, in addition to dilating blood vessels and promoting blood circulation, Mao Dongqing still has certain antibacterial and anti-inflammatory effects on infected wounds. After treatment, local inflammation was controlled, secretions were reduced, and redness was reduced. External use of pain, to rot, myogenic and other effects. After 3 to 5 days of treatment, the ulcer surface became dark and felt painful. However, the pain gradually decreased until it disappeared. The black and necrotic parts gradually fell off, and then the granulation grew rapidly. Even the epithelial tissue could repair itself and healed the wound. Due to the improvement of the blood circulation after treatment, the skin color of the affected part gradually turns from red to black, and the skin temperature also changes from cold to warm. The arterial pulse changes from unchanged to weak and finally returns to normal. The indications for this drug are better based on TCM syndrome differentiation, and the efficacy of partial yin type is poor. Even if other herbal medicines are added, the efficacy is not as good as the former. For some severe patients, the condition cannot be controlled quickly. There seems to be no absolute relationship between the duration of the disease and the efficacy. If you can adhere to medication for more than 4 months, the effect seems to be more satisfactory. How long-term efficacy remains to be further observed.
Dosage and Usage: An oral decoction: daily use 3 to 6 guinea root roots, or 0.5 to 1 jin, or to 1 to 2 jins, add 1 pig leg or pork, pork bone amount, decoction 2 to 3 or 1 Dayton clothing. 20 or 40 days for a course of treatment, each treatment interval can be several days to 1 week. The amount can be gradually increased. Two injections: preparations of different specifications, usage is also different, the general use of holly root 2 layers of skin or hairy holly leaves of the active ingredient, containing 2 grams per layer of holly root 2 grams of skin or 3 grams of holly leaves, each 2 ~ 4 ml, add 10 ml glucose solution 20 ml, intravenous injection, once a day, 30 days for a course of treatment, interval 7 ~ 10 days before the second course of treatment; or line arterial injection, each 2 ~ 4 Ml, plus 10% glucose 20 ml, 1 every other day, a total of 5 to 10 injections; also feasible intramuscular injection, each 2 to 4 ml, 1 to 2 times a day, 30 days for a course of treatment. Three topical decoctions: Mao Dongqing root 3 to 5 two or a half catties, Jianshui immersed limbs, 1 or 2 times a day, about half an hour each time, apply to ulcers with necrotic tissue wounds. Fresh granulation wounds should not be soaked. In addition, Mao Dongqing tablets and syrups are also available for internal use. In the course of treatment, Chinese medicine can be used in combination with syndrome differentiation of traditional Chinese medicine, and antibiotics and vitamins should be used properly in cases of severe gangrene infection. Ulcer wounds must still be combined with surgical treatment. There may be side effects such as nausea, vomiting, dizziness, etc. after taking the medicine, which may be relieved or disappeared within several days.
4 Treatment of burns
Mao Dongqing 1 kg, decoction 2 times, the filtrate was concentrated and concentrated into 50% decoction, made of oil gauze spare. Change the medication daily or every other day to keep the gauze wet. When the fever is high, another decoction is given orally, 20 to 40 ml each time, 2 to 3 times a day. According to preliminary observations, drainage after medication is good, there is anti-infective effect, the wound is fresh, and the irritatingness is small. Mao Dongqing can also be made into a cold cream and applied to the exposed wound surface. After 3 to 4 days, the wound will be scabbed and fall off on its own.
5 treatment of central retinitis
Intramuscular injection with Mao Dongqing injection, each 2 ml (containing flavonoids 40 mg), 1 or 2 times a day, according to more than 100 cases observed. The effective rate is above 90%, and the clinical cure rate is 34% or more. Visual acuity generally increases in about 1 week. In acute edema cases, the visual acuity improved rapidly and the curative effect was better. The visual recovery of chronic exudative patients was slower and the curative effect was poorer. When the visual acuity is restored to a certain level, the improvement will be slower and the medication must be continued. Some patients have a decreased visual acuity after stopping, but the remedy is still effective. A small number of cases relapsed during treatment and were caused by systemic disorders. Some patients had side effects such as dizziness, chest tightness, and fever after medication, and soon disappeared on their own without affecting treatment.
6 treatment of uveitis
Using Mao Dongqing's electrophoresis method, 1 to 2 times a day for 10 days as a course of treatment, combined with Mao Dongqing intramuscular injection, 1 to 2 times per day, each 2 ml (equivalent to 8 grams of crude drug); while using 1% atropine Eye pupil dilation. According to observations in 75 eyes of 60 patients, 66.6% were significantly effective. In particular, the role of inflammation of the anterior segment of the eye is more obvious, the average time of inflammation disappeared was 15 days, the fastest only 3 days. A few cases relapsed. It has been observed that Maodongqing has a hormone-like effect; it may promote the eye's blood circulation by dilating blood vessels in the eye, thereby improving eye nutrition and promoting the absorption of inflammatory products. In addition, Mao Dongqing had no effect on treating 3 cases of idiopathic uveitis. Therefore, it is believed that the indications of Mao Dongqing for uveitis still need further exploration.
7 treatment of atherosclerosis
8 others
It has been reported that the use of Mao Dongqing extract tablet was taken orally to treat two patients with no pulse, and the effect was not satisfactory. Treating children's pneumonia with Mao Dongqing injection showed that 31 cases (77.5%) were clinically cured, 7 cases (17.5%) were significantly improved, and 2 cases (0.5%) were ineffective. To soak gauze with raw liquid of hair holly, wet wound or stuffing the abscess for suppurative infection wounds; and for external use of Maodongqing solution for the treatment of eczema, pityriasis rosea, allergic dermatitis, prurigo nodularis and other skin diseases. Some effect. With 2% Maodongqing injection in the limb (referring to) after the replantation routine injections, each 20 to 40 mg. Twice a day, for two weeks, has a certain effect on the removal of postoperative vasospasm, which can greatly improve the success rate of surgery. 9 cases were observed (replantation of severed finger 6 cases, 3 cases of replantation of severed limbs). The results were successful except for one failure of replantation of severed finger. No postoperative vasospasm was found.
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