German scientists discover the culprit causing multiple cancers
Scientists from the German Cancer Research Center have found that the replacement of an amino acid in a metabolic enzyme is the culprit in many cancers.
Therefore, the German Cancer Institute and the Heidelberg University Hospital, Bayer jointly developed a synthetic substance that can prevent enzyme changes, and tested the mice to observe the expected effect of the composition.
Many malignant tumor developments are the result of genetic changes in a single cell. These genetic mutations often result in protein changes that provide cells with new substances that stimulate their growth. One of the most typical examples is the IDH1 enzyme associated with certain malignant brain tumors.
Scientists have noted that mutations in citrate dehydrogenase (IDH) always occur at specific locations in the amino acid chain of the enzyme, and this substitution results in the accumulation of metabolites that promote cancer cell growth in the cell.
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