Infrared light can trigger the hypersensitivity release of chemotherapy drugs, significantly enhancing the inhibitory effect on tumor growth
Infrared light can trigger the hypersensitivity release of chemotherapy drugs, significantly enhancing the inhibitory effect on tumor growth
October 12, 2016 Source: Drug Information Network
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];The latest research has found that polymer nano-drugs need to be released from nanocarriers in order to achieve more effective tumor killing effects after being enriched in tumor sites and taken up by tumor cells, and the polylactic acid system polymer nanomedicine currently used in clinical practice cannot be realized. This demand.
The school's nanomedicine and biomaterials team obtained a co-loaded nanosystem with a photothermal reagent and a chemotherapeutic drug, doxorubicin, and its core polymer material has a glass transition temperature as low as -81.8 °C. After 5 seconds of near-infrared light irradiation, the temperature of the nanoparticle solution rose slightly by 0.5 ° C ~ 1.5 ° C, and triggered the rapid hypersensitive release of chemotherapy drugs. Experiments have shown that in the case of chemotherapeutic drug enrichment at the tumor site, the hypersensitivity release of chemotherapeutic drugs triggered by near-infrared light can significantly enhance the ability to inhibit tumor growth. After 32 days of treatment, the tumor volume of the mice in the polyphosphate nanocarrier experimental group was only 1/3 of that of the polylactic acid nanotest group.
In the first generation of polylactic acid macromolecular drugs currently used clinically, since the glass transition temperature of polylactic acid is as high as 40.2 ° C, the polylactic acid segment is still in a glass state during photothermal conversion, and the entire polymer chain cannot Exercise, which led to the inhibition of chemotherapy drug movement, was not observed in this hypersensitive release effect.
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