Shocked: This genetic mutation can make the brain age for twelve years.
People of the same age may look younger or older, and a recent study from the Columbia University Medical Center shows that the same is true for human brains, which can accelerate the brain aging of some people for 12 years. The study was published in the Cell magazine, Cell Systems.
Although their study does not specifically target neurodegenerative diseases such as Alzheimer's disease, this study may help develop a novel biomarker for assessing the effects of anti-aging treatments and at the same time becoming relevant for treating aging. The drug target of the disease.
The team looked at 1904 samples from the brains of older people without neurodegenerative diseases. They first tested the transcriptome of each sample—the initial product of gene expression, and then compared it with the average transcriptome of peers. Find mutants that increase the "difference" age. This difference means that people of the same age may have brains of different physiological ages.
“There is a mutant that stands out: TMEM106B,†said Dr. Herve Rhinn, an assistant professor at the University of Columbia's Taub Institute, one of the leading researchers. “This is very common. About one-third have two copies, another three points. One of the people has a copy."
The frontal cortex of a person with two copies of the wrong gene will be 12 years older than a person with two normal copies, said Professor Asa Abeliovich, one of the leading researchers and also from the Taub Institute. The frontal cortex is responsible for advanced brain activities, including memory, thinking, and emotions.
â–² Dr. Herve Rhinn from the University of Columbia's Taub Institute (Source: Columbia University Taub Institute)
â–² Professor Asa Abeliovich of the University of Columbia's Taub Institute (Source: Columbia University Taub Institute)
Auto Hematology Analyzer,Clinical Hematology Analyzer,Blood Analyzer Hematology,Hematology Analyzer
Guangdong Widinlsa International Co.Ltd , https://www.widinlsamachine.com