3D nanoprinting replication brain neural network: already omnipotent
The omnipotent 3D printing technology seems to be infiltrating into the field of brain science. Just two weeks ago, scientists who reported that Scotland were using 3D printed brain tumor replicas to promote cancer research. Now, researchers at Aston University in the UK go further: through the MESO-BRAIN project, they will use 3D nanoprinted stents to construct artificial neural networks and use them to study brain development and disease. .
On June 9, 2016, the MESO-BRAIN research team stated that they have received €3.3 million in research funding from the European Commission through its Future and Emerging Technologies (FET)-funded projects.
It is understood that the MESO-BRAIN project will use human induced pluripotent stem cells to differentiate into neurons on a well-defined and reproducible 3D scaffold to support the development of human neural networks that mimic human brain activity.
The researchers say the structure is based on a brain-based cortical module design that uses nanoscale 3D laser printing to print the structure and incorporate nano-electrodes to achieve electrophysiology of the neural network. analysis.
The MESO-BRAIN project also plans to use a fast volumetric imaging technology based on light illumination for optical analysis to achieve cell-level resolution across the entire 3D network.
It is reported that the project's goals include simulating brain activity and improving awareness and treatment of many brain diseases including Parkinson's disease, Alzheimer's disease and brain damage. MESO-BRAIN is also expected to enable large-scale human cell-based assays to test the regulatory effects of pharmacological and toxicological compounds on neural network activity.
Researchers believe that the use of more physiologically relevant human models will increase the efficiency of drug screening and reduce the need for animal experiments.
The MESO-BRAIN project will be officially launched in September this year and is expected to last more than three years. The project leader, Professor Edik Rafailov of Aston University, said in a statement: "Until recently, what we hope to achieve through this project is still in the category of science fiction. If they can really print from the brain through 3D nano-printing If you extract and copy the neural network, then this will no longer be a science fiction."
It is understood that the research work of the MESO-BRAIN project will be led by Aston University, and other participating institutions include Axol Bioscience, Hannover Laser Center, University of Barcelona, ​​Photonics Science Institute and KITE Innovation.
PET is part of the European Commission's Research and Innovation Funding Framework Program, Horizon 2020, under which the EU will invest 80 billion euros in research in seven years (2014-2020).
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