Major progress in antibacterial research in the Department of Chemistry of the University of Hong Kong

2023-05-27 08:10:41

September 01, 2016 Source: Science Network

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Recently, the reporter learned from the University of Hong Kong that the team of the Associate Professor Li Xuechen of the University of Hong Kong and his partners at the University of Florida and the Hong Kong Polytechnic University jointly published the new antibiotic Teixobactin in the international academic journal Nature Communications. Synthesis of research results. Teixobactin is the first new antibiotic to be discovered in the past 30 years. Its chemical synthesis also lays the foundation for the application and development of a new generation of antibiotics.

In the past seven years, Li Xuechen and his research team have been working hard to develop new antibiotics. In 2013, they used the chemical method to synthesize daptomycin for the first time. Based on this, they developed a new generation of daptomycin antibacterial drugs. Recently, the team of Li Xuechen successfully synthesized the popular antibacterial compound Teixobactin by chemical synthesis.

The new antibiotic Teixobactin was discovered by American scientists in 2015 and has achieved a huge breakthrough in the field of antibacterial drugs, which can kill methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), and tuberculosis. The most critical of many deadly pathogens such as Mycobacterium, Teixobactin does not induce bacterial resistance. Chemical synthesis is the only method that can flexibly modify chemical structures with simple starting materials and obtain a large number of teixobactin derivatives. Therefore, the chemical synthesis of Teixobactin has attracted close attention and fierce competition from multiple research teams around the world. In collaboration with a chemical laboratory at the University of Central Florida, Li Xuechen's research team became one of the first laboratories in the world to successfully develop the synthetic route to Teixobactin. Based on the synthetic methods they developed, the research team has synthesized 10 promising Texobactin analogues (which have been applied for US interim patents), and their synthetic pathways allow rapid and efficient synthesis of a variety of Teixobactin derivatives. In the next two years, they will work to synthesize 100 different Teixobactin derivatives to improve their efficacy and apply to clinical research.

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